May 2020
Vol 5, Issue 47

About The Cover

Cover image expansion

ONLINE COVER Sugarcoated Vaccine. This month's cover illustration depicts the trimeric pre-fusion (pre-F) protein of respiratory syncytial virus (RSV) found in an engineered nanoparticle vaccine construct. Swanson et al. describe the synthesis and preclinical testing of an RSV vaccine candidate consisting of eight of these pre-F spikes attached to a ferritin core. The magenta-colored branched glycans engineered onto the protein surface shield poorly neutralizing epitopes on pre-F, allowing antibody responses to focus instead on the known neutralizing epitopes indicated by red patches. [CREDIT: K. SWANSON ET AL./SCIENCE IMMUNOLOGY]